After Humayun set out from his expedition in Sindh, along with 300 camels (mostly wild) and 2000 loads of grain, he set off to join his brothers in Kandahar after crossing the Indus River on 11 July 1543 along with the ambition to regain the Mughal Empire and overthrow the Suri dynasty. Among the tribes that had sworn allegiance to Humayun were the Leghari, Magsi, Rind and many others.
Humayun fled to the refuge of the Safavid Empire in Persia, marching with 40 men, his wife Bega Begum, and her companion through mountains and valleys. Humayun's exile in Persia established diplomatic ties between the Safavid and Mughal Courts, and led to increasing Persian cultural influence in the Mughal Empire.
Shah Tahmasp urged that Humayun convert from Sunni to Shia Islam, and Humayun eventually accepted, in order to keep himself and several hundred followers alive. Shah staged a celebration for Humayun, with 300 tents, an imperial Persian carpet, 12 musical bands and "meat of all kinds". Here the Shah announced that all this, and 12,000 elite cavalry were his to lead an attack on his brother Kamran. All that Shah Tahmasp asked for was that, if Humayun's forces were victorious, Kandahar would be his.