Tsakanin 1258 zuwa 1291, yankin ya fuskanci tashin hankali a matsayin iyaka tsakanin mahara Mongol , lokaci-lokaci tare da 'yan Salibiyya , daMamluks naMasar .Wannan rikici ya haifar da raguwar yawan jama'a da matsalolin tattalin arziki.Mamluk dai galibinsu ‘yan asalin kasar Turkiyya ne, kuma ana saye su tun suna yara sannan kuma aka horar da su kan yaki.Sun kasance jarumawa masu daraja sosai, waɗanda suka ba wa masu mulki 'yancin kai na 'yan mulkin mallaka.A kasar Masar sun karbe ragamar mulkin kasar biyo bayan wani hari da 'yan Salibiyya suka yi musu (Crusade na bakwai).Mamluk sun mamaye Masar kuma suka fadada mulkinsu zuwa Palastinu.Mamluk Sultan na farko Qutuz ya yi galaba a kan Mongolawa a yakin Ain Jalut, amma Baibars suka kashe shi, wanda ya gaje shi ya kawar da mafi yawan sansanonin 'yan Salibiyya.Mamluks sun yi mulkin Falasdinu har zuwa 1516, game da ita a matsayin wani yanki na Siriya.A Hebron, Yahudawa sun fuskanci ƙuntatawa a Kogon Kakanni, wani muhimmin wuri a cikin addinin Yahudanci, iyakance wanda ya ci gaba har zuwa Yaƙin Kwanaki Shida.^[146]Al-Ashraf Khalil, Sarkin Mamluk, ya kwace tungar 'yan Salibiyya ta karshe a shekara ta 1291. Mamluks, ci gaba da manufofin Ayyubid, sun lalata yankunan bakin teku daga Taya zuwa Gaza da dabara don hana kai hare-hare a tekun 'yan Salibiyya.Wannan barnar ta haifar da raguwar yawan jama'a da koma bayan tattalin arziki a wadannan yankuna.^[147]Al'ummar Yahudawa a Falasdinu sun ga farfadowa tare da kwararar Yahudawan Sephardic bayan korar su dagaSpain a 1492 da kuma tsanantawa a Portugal a 1497. A karkashin Mamluk da kuma daga baya mulkin Ottoman , wadannan Sephardic Yahudawa sun zama mafi rinjaye a cikin birane kamar Safed da Jerusalem, sabanin da galibin al'ummar Yahudawan Musta'arbi na karkara.^[148]