Yaƙin Byzantine–Sasaniya na 602–628 shine na ƙarshe kuma mafi muni na jerin yaƙe-yaƙe da aka yi tsakanin Daular Rumawa da Daular Sasaniya ta Iran .Wannan ya zama rikici na tsawon shekarun da suka gabata, yakin mafi tsayi a cikin jerin, kuma an yi yakin gabas ta tsakiya: aMisira , Levant, Mesopotamiya , Caucasus, Anatolia, Armenia , Tekun Aegean da kuma gaban ganuwar Constantinople kanta.A karshen rikicin, bangarorin biyu sun yi amfani da karfin dan Adam da abin duniya, kuma sun cimma kadan.A sakamakon haka, sun kasance cikin rauni ga bullar khalifancin Rashidun Islama kwatsam, wanda dakarunta suka mamaye daulolin biyu bayan ƴan shekaru kaɗan bayan yaƙin.