Yakin Ottoman-Safavid na 1623-1639 shi ne na karshe na jerin tashe-tashen hankula da aka gwabza tsakanin Daular Usmaniyya da Daular Safavid , sannan manyan kasashe biyu na Yammacin Asiya, kan iko da Mesopotamiya.Bayan nasarar farko da Farisa suka yi wajen kwato Bagadaza da galibin kasar Iraki ta zamani, bayan da suka yi asararsa tsawon shekaru 90, yakin ya zama mai daure kai yayin da Farisawa suka kasa kara matsawa zuwa cikin Daular Usmaniyya, kuma yakin da ake yi a Turai ya dauke hankalin Ottoman da kansu. ta cikin hargitsi.Daga karshe dai Daular Usmaniyya sun sami nasarar kwato Bagadaza, inda suka yi tafka asara mai yawa a yakin karshe, kuma sanya hannu kan yerjejeniyar Zuhab ya kawo karshen yakin da nasarar Ottoman.Kusan a magana, yarjejeniyar ta maido da iyakokin 1555, tare da Safavids sun kiyaye Dagestan, gabashin Jojiya , Armenia ta gabas, da Jamhuriyar Azerbaijan ta yau, yayin da yammacin Jojiya da yammacin Armeniya suka shiga karkashin mulkin Ottoman.Gabashin Samtskhe (Meskheti) ya ɓace ba tare da ɓata lokaci ba ga Ottomans da kuma Mesofotamiya.Duk da cewa Iraniyawa sun sake kwace wasu sassan Mesofotamiya a takaice daga baya a tarihi, musamman a zamanin mulkin Nader Shah (1736-1747) da Karim Khan Zand (1751-1779), tun daga nan ya kasance a hannun Ottoman har zuwa bayan yakin duniya na daya. .