Vasili III ya ci gaba da manufofin mahaifinsa Ivan III kuma ya shafe yawancin mulkinsa yana ƙarfafa ribar Ivan.Vasili ya haɗa lardunan da suka tsira na ƙarshe: Pskov a 1510, ƙawancen Volokolamsk a 1513, mulkokin Ryazan a 1521 da Novgorod-Seversky a 1522. Vasili kuma ya yi amfani da matsananciyar matsayi na Sigismund na Poland don kama Smolensk, babbar babbar ƙasar Poland. na Lithuania, musamman ta hanyar taimakon dan tawayen Lithuania, Yarima Mikhail Glinski, wanda ya ba shi makamai masu linzami da injiniyoyi.A shekara ta 1521 Vasili ya karbi jakadan daular Safawad ta Iran da ke makwabtaka da shi, wanda Shah Ismail I ya aiko wanda burinsa shi ne gina kawancen Iran da Rasha kan abokan gaba, daular Usmaniyya .Vasili ya yi nasara daidai da Crimean Khanate.Ko da yake a shekara ta 1519 ya zama dole ya saya daga Crimean Khan, Mehmed I Giray, a karkashin ganuwar Moscow, a karshen mulkinsa ya kafa tasiri na Rasha a kan Volga.A cikin 1531-32 ya sanya mai yin riya Cangali khan a kan karagar Khanate na Kazan.Vasili shine babban sarki na farko na Moscow wanda ya karbi lakabin tsar da mikiya mai kai biyu na Daular Byzantine.