Yaƙin Achaemenid na kwarin Indus ya faru ne daga ƙarni na 6 zuwa na 4 KZ, kuma ya ga Daular Farisa ta Achaemenid ta mallaki yankuna ayankin arewa maso yammacin Indiya waɗanda galibi suka ƙunshi yankin Pakistan na zamani.Na farko daga cikin manyan mamayewa guda biyu an gudanar da shi a kusan 535 KZ ta wanda ya kafa daular, Cyrus the Great, wanda ya mamaye yankuna yammacin kogin Indus wanda ya kafa iyakar gabashin Daular Achaemenid.Bayan mutuwar Sairus, Darius Mai Girma ya kafa daularsa kuma ya fara sake mamaye tsoffin larduna kuma ya kara fadada daular.Kusan 518 KZ, sojojin Farisa karkashin Darius sun ketare Himalayas zuwa Indiya don fara lokaci na biyu na cin nasara ta hanyar mamaye yankuna har zuwa kogin Jhelum a Punjab.Tabbatacciyar shaida ta farko ta hanyar rubutun Behistun yana ba da kwanan wata kafin ko kusan 518 KZ.Shigar Achaemenid zuwa cikin yankin Indiya ya faru ne a matakai, farawa daga sassan arewacin kogin Indus kuma yana motsawa zuwa kudu.An shigar da kwarin Indus bisa ƙa'ida a cikin Daular Achaemenid a matsayin satrapies na Gandāra, Hindush, da Sattagydia, kamar yadda aka ambata a cikin rubuce-rubucen Farisa na zamanin Achaemenid da yawa.Mulkin Achaemenid akan kwarin Indus ya ragu akan sarakunan da suka biyo baya kuma ya ƙare a ƙa'ida a lokacin yaƙin Macedonia na Farisa a ƙarƙashin Alexander the Great.Wannan ya haifar da sarakuna masu zaman kansu irin su Porus (mai mulkin yankin tsakanin kogin Jhelum da Chenab), Ambhi (mai mulkin yankin tsakanin kogin Indus da Jhelum tare da babban birninta a Taxila) da kuma gaṇasaṅghas, ko jumhuriya, wanda daga baya. ya fuskanci Alexander a lokacin yakin Indiya a kusa da 323 KZ.Daular Achaemenid ta kafa tsarin mulki ta hanyar amfani da satrapies, wanda daular Alexander ta Makidoniya, Indo-Scythians, da daular Kushan suka ci gaba da aiwatarwa.