A cikin 1537, yana ba da umarni ga manyan jiragen ruwa na Ottoman, Hayreddin Barbarossa ya kama wasu tsibiran Aegean da Ionian na Jamhuriyar Venice , wato Syros, Aegina, Ios, Paros, Tinos, Karpathos, Kasos, da Naxos, don haka ya haɗa Duchy na Naxos. zuwa Daular Usmaniyya.Daga nan bai yi nasara ba ya kewaye sansanin Venetian na Corfu kuma ya lalata gabar tekun Calabrian da ke hannunSpain a kudancin Italiya.A cikin fuskantar wannan barazanar, Paparoma Paul III a cikin Fabrairu 1538 a cikin taron '' Holy League '', wanda ya ƙunshi jihohin Papal, Hapsburg Spain, Jamhuriyar Genoa , Jamhuriyar Venice, da Knights na Malta, don fuskantar Ottoman. jiragen ruwa a karkashin Barbarossa.Ottoman ya ci nasara a yakin Preveza kuma, tare da nasara na gaba a yakin Djerba a 1560, Ottomans sun yi nasara wajen tunkude kokarin Venice da Spain, manyan masu adawa da juna a Bahar Rum, don dakatar da yunkurinsu na sarrafa teku. .Sarautar Daular Usmaniyya a manyan fadace-fadacen jiragen ruwa a Tekun Bahar Rum ya kasance ba a kalubalanta ba har zuwa yakin Lepanto a shekara ta 1571. Yana daya daga cikin manyan fadace-fadacen teku guda uku da aka yi a karni na sha shida na Mediterranean, tare da yakin Djerba da yakin. da Lepanto.