Kusan 208 Vologases VI ya gaji mahaifinsa Vologases V a matsayin sarkin Daular Arsacid.Ya yi sarauta a matsayin sarkin da ba a yi takara ba daga shekara ta 208 zuwa 213, amma daga baya ya fada cikin gwagwarmayar daular da dan uwansa Artabanus IV, wanda a shekara ta 216 ke rike da mafi yawan daular, har ma daular Roma ta amince da shi a matsayin babban sarki.Iyalin Sasaniya sun yi fice cikin sauri a cikin ƙasarsu ta Pars, kuma yanzu a ƙarƙashin yarima Ardashir I sun fara cin nasara kan yankuna makwabta da wasu yankuna masu nisa, kamar Kirman.Da farko dai ayyukan Ardashir na 1 bai firgita Artabanus na IV ba, sai daga baya Sarkin Arsacid ya zabi ya tunkari shi.Yakin Hormozdgan shi ne yakin karshe tsakanin daular Arsacid da Sasania wanda ya gudana a ranar 28 ga Afrilu, 224. Nasarar Sasaniya ta karya karfin daular Parthia , wanda ya kawo karshen kusan karni biyar na mulkin Parthia a Iran , tare da nuna alamar hukuma a hukumance. farkon zamanin Sasaniya.Ardashir Na ɗauki lakabin shahanshah ("Sarkin Sarakuna") kuma na fara mamaye wani yanki da ake kira Iranshahr (Ērānshahr).Sojojin Ardashir na I sun kori Vologases VI daga Mesofotamiya jim kadan bayan shekara ta 228. Manyan iyalan Parthian (wanda aka fi sani da manyan gidaje bakwai na Iran) sun ci gaba da rike madafun iko a Iran, yanzu tare da Sasaniyawa a matsayin sabbin sarakunan su.Sojojin Sasaniya na farko (spah) sun kasance daidai da na Parthia.Lallai, yawancin sojojin dokin Sasaniya sun ƙunshi manyan sarakunan Parthia waɗanda suka taɓa yi wa Arsacids hidima.Wannan yana nuna cewa Sasaniyawa sun gina daularsu saboda goyon bayan sauran gidajen Parthia, kuma saboda haka ake kiranta "daular Farisa da Farisa".