Na farko, Shah Tahmasp ya kashe gwamnan Bagadaza mai biyayya ga Suleiman, kuma ya sanya nasa mutum a ciki. Na biyu, gwamnan Bitlis ya koma ya yi mubaya'a ga Safawiyawa .Sakamakon haka, a shekara ta 1533, Suleiman ya umarci Pargalı Ibrahim Pasha da ya jagoranci runduna zuwa gabashin Asia Minor inda ya sake kwace Bitlis ya mamaye Tabriz ba tare da turjiya ba.Suleiman ya shiga cikin Ibrahim a shekara ta 1534. Sun yi tururuwa zuwa Farisa , sai kawai suka sami Shah yana sadaukar da yankin maimakon fuskantar yakin da ake yi, inda suka yi ta cin zarafin sojojin daular Usmaniyya yayin da suke tafiya cikin tsaka mai wuya.A cikin 1535 Suleiman ya yi babbar shiga Baghdad.Ya inganta goyon bayansa na cikin gida ta hanyar maido da kabarin Abu Hanifa, wanda ya assasa mazhabar Hanafiyya ta shari'ar Musulunci wanda daular Usmaniyya suka yi riko da shi.