Mohammad Khodabanda shi ne Safawid shah na Iran na hudu daga shekara ta 1578 har zuwa 1587 da dansa Abbas I. Khodabanda ya hambarar da shi a matsayin dan uwansa Ismail II.Khodabanda ɗa ne ga Shah Tahmasp I ta mahaifiyar Turcoman, Sultanum Begum Mawsillu, kuma jikan Ismail I, wanda ya kafa daular Safavid.Bayan rasuwar mahaifinsa a shekara ta 1576, Khodabanda ya rasu a madadin kaninsa Ismail II.Khodabanda yana fama da ciwon ido wanda ya sa shi kusan makanta, don haka bisa ga al'adar Masarautar Farisa ba zai iya yin takara da karagar mulki ba.Duk da haka, bayan gajeriyar mulkin Ismail II Khodabanda ya zama magaji tilo, don haka tare da goyon bayan kabilun Qizilbash ya zama Shah a shekara ta 1578.Mulkin Khodabanda ya sami ci gaba da raunin rawani da fadace-fadacen kabilanci a zaman wani bangare na yakin basasa na biyu na zamanin Safavid.An siffanta Khodabanda a matsayin "mutum mai tsaftataccen dandano amma mai rauni".A sakamakon haka, mulkin Khodabanda ya kasance da bangaranci, tare da manyan kabilu sun daidaita kansu tare da 'ya'yan Khodabanda da magada na gaba.Wannan hargitsin cikin gida ya baiwa kasashen waje musamman masu adawa da daular Usmaniyya da ke makwabtaka da su damar samun galaba a cikin yankuna, ciki har da mamaye tsohon babban birnin Tabriz a shekara ta 1585. A karshe dai aka kifar da Khodabanda a wani juyin mulki da aka yi don goyon bayan dansa Shah Abbas na farko.