Burma , karkashin jagorancin Sarki Bayinnaung, sun ci Chiang Mai, inda suka kafa mulkin Burma na shekaru 200 akan Lan Na.Rikici ya taso a kan jihohin Shan, tare da fadada burin Bayinnaung wanda ya kai ga mamaye Lan Na daga arewa.A cikin 1558, Mekuti, mai mulkin Lan Na, ya mika wuya ga Burma a ranar 2 ga Afrilu 1558. ^[17]A lokacin Yaƙin Burma – Siamese (1563–64), Mekuti ya yi tawaye tare da ƙarfafawa daga Setthathirat.Duk da haka, sojojin Burma sun kama shi a shekara ta 1564 kuma suka kai shi Pegu, babban birnin Burma a lokacin.Bayinnaung ya nada Wisutthithewi, dan sarautar Lan Na, a matsayin sarauniyar Lan Na bayan mutuwar Mekuti.Daga baya, a cikin 1579, ɗaya daga cikin ƴan Bayinnaung, Nawrahta Minsaw, ^[18] ya zama mataimakiyar Lan Na.Yayin da Lan Na ya ji daɗin 'yancin kai, Burma yana sarrafa aiki da haraji sosai.Bayan zamanin Bayinnaung, daularsa ta wargaje.Siam yayi nasarar yin tawaye (1584–93), wanda ya kai ga rugujewar vassals na Pegu ta 1596–1597.Lan Na, karkashin Nawrahta Minsaw, ya ayyana 'yancin kai a shekara ta 1596 kuma a taƙaice ya zama masarautar Siam ta Sarkin Naresuan a shekara ta 1602. Duk da haka, ikon Siam ya ragu bayan mutuwar Naresuan a 1605, kuma ya zuwa 1614, yana da ikon mallakar Lan Na.Lan Na ya nemi taimako daga Lan Xang maimakon Siam lokacin da Burma ya dawo.^[19] Sama da karni daya bayan 1614, sarakunan vassal na zuriyar Burmese sun yi mulkin Lan Na, duk da ƙoƙarin Siam na tabbatar da iko a 1662-1664, wanda a ƙarshe ya gaza.