Bayan da aka kewaye Rhodes, a cikin 1526 Suleiman ya yi balaguro na biyu don mamaye dukan ƙasar Hungary.A cikin tsakiyar watan Yuli, Sarkin matashi ya tashi daga Buda, ya ƙudura don "ko dai ya yaƙi mahara ko kuma a murkushe shi gaba ɗaya".Louis ya yi kuskuren dabara lokacin da ya yi ƙoƙarin dakatar da sojojin Ottoman a fagen yaƙin buɗe ido tare da runduna ta tsakiya, rashin isassun bindigogi, da dabarun da ba su da amfani.A ranar 29 ga Agusta 1526, Louis ya jagoranci sojojinsa a kan Suleiman a cikin mummunan yakin Mohács.Sojojin kasar Hungary sun yi kawanya da dakarun dawakan Ottoman a cikin wani yunkuri na tsageru, kuma a tsakiyar kasar an fatattaki manyan mayaka da sojojin kasar Hungarian, inda aka yi ta fama da munanan raunuka, musamman daga makaman daular Usmaniyya da ke da kyau da kuma makami masu kyau da horaswa na Janissary.An lalata kusan dukkanin sojojin Masarautar Hungary cikin kusan sa'o'i 2 a fagen daga.A lokacin da ake ja da baya, sarkin mai shekaru ashirin ya mutu lokacin da ya fado baya daga kan dokinsa yayin da yake kokarin haye wani babban rafi na kogin Csele.Ya fada cikin rafi, saboda nauyin sulkensa, ya kasa tashi ya nutse.Da yake Louis ba shi da 'ya'ya na gaskiya, an zaɓi Ferdinand a matsayin magajinsa a Masarautar Bohemia da Hungary , amma John Zápolya ya yi hamayya da kursiyin Hungarian, wanda ya mulki yankunan daular da Turkawa suka ci a matsayin abokin ciniki na Ottoman.