Yakin Sasaniya na Kudus wani muhimmin lamari ne a yakin Byzantine-Sasaniya na 602-628, wanda ya faru a farkon shekara ta 614. A cikin rikici, Sarkin Sasaniya Khosrow II ya nada Shahrbaraz, spahbod (shugaban sojoji), ya jagoranci kai hari. cikin Diocese na Gabashin Daular Byzantine .A karkashin Shahrbaraz, sojojin Sasaniya sun sami nasara a Antakiya da kuma a Caesarea Maritima, babban birnin gudanarwa na Palaestina Prima.^{[134 <>]} A wannan lokacin, babbar tashar jiragen ruwa ta ciki ta yi rufin asiri kuma ba ta da amfani, amma birnin ya ci gaba da kasancewa muhimmiyar tashar ruwa bayan da Sarkin Byzantine Anastasius I Dicorus ya ba da umarnin sake gina tashar jiragen ruwa.Nasarar kwace birnin da tashar jiragen ruwa ya baiwa Daular Sasani ta hanyar dabarun shiga Tekun Bahar Rum.^[135] Ci gaban Sasaniyawa ya kasance tare da fashewar tawayen Yahudawa ga Heraclius;sojojin Sasaniya sun haɗu da Nehemiah ben Hushiel ^[136] da Biliyaminu na Tiberias, waɗanda suka yi rajista da kuma makamai Yahudawa daga ko'ina cikin Galili, ciki har da biranen Tiberias da Nazarat.Gabaɗaya, ’yan tawayen Yahudawa 20,000 zuwa 26,000 ne suka shiga farmakin Sasaniya a Urushalima.^{[137 <>]} A tsakiyar shekara ta 614, Yahudawa da Sasaniyawa sun mamaye birnin, amma majiyoyi sun bambanta a kan ko hakan ya faru ba tare da juriya ba ^[134] ko kuma bayan wani shinge da keta bango da bindigogi.Bayan da Sasaniyawa suka kwace birnin Kudus dubun dubatar Kiristocin Rumawa ne ‘yan tawayen yahudawa suka yi wa kisan kiyashi.