Babban rikici na farko tsakanin mahara Larabawa da sojojin Farisa a Mesopotamiya ya faru ne a shekara ta 634 AD a yakin gada.A nan, rundunar musulmi ta kusan 5,000, karkashin jagorancin Abu ‘Ubayd ath-Thaqafi, ta sha kashi a hannun Farisawa .Wannan koma baya ya biyo bayan nasarar da Khalid bn al-Walid ya yi, wanda ya sa Larabawa suka mamaye kusan dukkanin kasar Iraki a cikin shekara guda, in ban da Ctesiphon, babban birnin Farisa.Wani muhimmin lokaci ya zo a kusan shekara ta 636 AZ, lokacin da wata babbar rundunar musulmi ta Larabawa karkashin Sa'ad ibn Abi Waqqas ta fatattaki babban sojojin Farisa a yakin al-Qadisiyyah.Wannan nasara ta share fagen kamo Ctesiphon.A ƙarshen shekara ta 638 AZ, Musulmai sun ci dukan lardunan Sassanid na Yamma, ciki har da Iraki ta zamani.Sarkin Sassanid na ƙarshe, Yazdegerd III, ya fara gudu zuwa tsakiya sannan kuma arewacin Farisa, inda aka kashe shi a shekara ta 651 AD.Yaƙe-yaƙe na Musulunci sun yi alama mafi girman faɗaɗa Semitic a tarihi.Masarakan Larabawa sun kafa sabbin garuruwan sansanin sojoji, musamman al-Kūfah kusa da tsohuwar Babila da Basrah a kudu.Duk da haka, arewacin Iraki ya kasance mafi rinjayen Assuriyawa da Kiristanci na Larabawa.