Masarautar Cambodia tana tsakiya ne a Mekong, tana samun ci gaba a matsayin wani muhimmin sashi na cibiyar kasuwanci ta tekun Asiya, ^[69] ta hanyar da aka fara tuntuɓar masu binciken Turai da masu fafutuka.^{[70 <>]} A karni na 17 Siam da Vietnam sun ƙara fafatawa a kan kula da rafin Mekong mai albarka, suna ƙara matsa lamba kan raunanar Cambodia.Wannan shine farkon dangantakar kai tsaye tsakanin Angkor Cambodia da Vietnam.Vietnamese akan "Maris ta Kudu" sun isa Prei Nokor/Saigon a Mekong Delta a karni na 17.Wannan taron ya fara tafiyar hawainiya da Cambodia ke rasa damar shiga teku da kasuwancin ruwa mai zaman kansa.^[71]