Bayan sun ci yakin Ajnadayn ne sojojin musulmi suka yi tattaki zuwa arewa inda suka kewaye Damascus.Don keɓe birnin daga sauran yankunan Khalid ya sanya runduna ta kudu a kan hanyar zuwa Palastinu da kuma a arewa a kan hanyar Damascus-Emesa, da kuma wasu ƙananan ƙananan hanyoyi a kan hanyoyin Damascus.An kama dakarun Heraclius tare da fatattake su a yakin Sanita-al-Uqab, mai tazarar kilomita 30 (mil 20) daga Damascus.Sojojin Khalid sun yi tir da ’yan salien Rumawa guda uku wadanda suka yi kokarin karya kewayen.An kwace birnin ne bayan wani bishop mai ra'ayin addini ya sanar da Khalid ibn al-Walid, babban kwamandan musulmi, cewa mai yiyuwa ne a keta katangar birnin ta hanyar kai hari a wani wuri da aka kare da safe kawai.Yayin da Khalid ya shiga birnin ta hanyar hari daga kofar Gabas, Thomas, kwamandan sojojin Rumawa, ya yi shawarwarin mika wuya cikin lumana a kofar Jabiya tare da Abu Ubaidah, na biyu na Khalid.Bayan mika wuyan birnin, kwamandojin sun yi sabani kan sharuddan yarjejeniyar zaman lafiya.Damascus shi ne babban birni na farko na Daular Rumawa ta Gabas da ya fado a lokacin mamayar da musulmi suka yi a Siriya.