Yaƙin Burma-Siamese (1759-1760) shine rikicin soja na farko tsakanin daular Konbaung na Burma (Myanmar) da daular Ban Phlu Luang na masarautar Ayutthaya ta Siam.Ya jagoranci rikicin da aka kwashe shekaru aru-aru a tsakanin kasashen biyu na kudu maso gabashin Asiya wanda zai dau tsawon wani karni.Burma sun kasance "a kan gaɓar nasara" kwatsam sai suka janye daga kewayen Ayutthaya saboda sarkinsu Alaungpaya ya kamu da rashin lafiya.^[46] Ya rasu bayan makonni uku, ya kawo karshen yakin.Casus belli sun kasance kan kula da gabar Tenasserim da kasuwancinsa, ^[47] da goyon bayan Siamese ga 'yan tawayen kabilar Mon na Masarautar Hanthawaddy da aka dawo da su.^[46] Sabuwar daular Konbaung da aka kafa ta so ta sake kafa ikon Burma a babban gabar Tenasserim (jihar Mon ta yau) inda Siamese suka ba da tallafi ga 'yan tawayen Mon tare da tura sojojinsu.Siamese sun ki amincewa da bukatar Burma na mika shugabannin Mon ko kuma su daina kutsawa cikin abin da Burma ke daukar yankinsu.^[48]Yaƙin ya fara ne a cikin Disamba 1759 lokacin da sojojin Burma 40,000 karkashin jagorancin Alaungpaya da dansa Hsinbyushin suka mamaye gabar Tenasserim daga Martaban.Shirin yaƙin nasu shine su zagaya wuraren da Siamese ke karewa tare da gajeru, hanyoyin mamayewa kai tsaye.Dakarun mamayar sun mamaye kariyar Siamese masu sirara a bakin teku, suka ketara tudun Tenasserim zuwa gabar Tekun Siam, suka juya arewa zuwa Ayutthaya.Abin da ya ba su mamaki, Siamese sun yunƙura don saduwa da Burma a kudancin su, kuma suka kafa matakan tsaro masu ruɗi a kan hanyar zuwa Ayutthaya.Amma sojojin kasar Burma masu tsananin fada sun sami galaba a kan tsaron Siamese masu yawan gaske kuma suka isa wajen babban birnin kasar Siamese a ranar 11 ga Afrilun 1760. Amma kwanaki biyar kacal da kewayen, ba zato ba tsammani sarkin Burma ya kamu da rashin lafiya kuma umurnin Burma ya yanke shawarar janyewa.Ingantacciyar aikin gadi na Janar Minkhaung Nawrahta ya ba da izinin janyewa cikin tsari.^[49]Yakin bai cika ba.Yayin da Burma suka sake samun iko da babban teku har zuwa Tavoy, ba su kawar da barazanar da suke da shi a yankunan da ke kewaye ba, wanda ya kasance mai tsanani.An tilasta musu su yi maganin tawayen kabilanci masu goyon bayan Siamese a bakin teku (1762, 1764) da kuma Lan Na (1761-1763).