Yaƙin Toungoo-Ava wani rikici ne na soja wanda ya faru a Ƙasar ƙasa da Tsakiyar Burma (Myanmar) a yau tsakanin Daular Toungoo, da Ƙungiyar Ava-Jagorancin Jihohin Shan, Hanthawaddy Pegu, da Arakan (Mrauk-U).Nasarar da Toungoo ta samu ya ba daular farko ta iko da dukkan tsakiyar Burma, kuma ta tabbatar da fitowar ta a matsayin siyasa mafi girma a Burma tun faduwar Daular Maguzawa a 1287. ^[45]Yaƙin ya fara ne a cikin 1538 lokacin da Ava, ta hanyar Prome vassal, ya ba da goyon bayan Pegu a yakin shekaru hudu tsakanin Toungoo da Pegu.Bayan da sojojinta suka karya shingen Prome a cikin 1539, Ava ta sami abokantaka na Confederation sun amince su shirya yaki, kuma suka kulla kawance da Arakan.^[46] Amma rashin daidaituwar ƙawancen ya gaza buɗe gaba na biyu a cikin watanni bakwai na busasshen lokacin 1540-41 lokacin da Toungoo ke ƙoƙarin cin nasara Martaban (Mottama).Ƙungiyoyin sun kasance da farko ba tare da shiri ba lokacin da sojojin Toungoo suka sake sabunta yakin da Prome a watan Nuwamba 1541. Saboda rashin daidaituwa, sojojin Ava-Jagoranci Confederation da Arakan sun kori baya da mafi kyawun sojojin Toungoo a cikin Afrilu 1542, bayan haka sojojin ruwa na Arakanese. wanda tuni ya ɗauki tashar jiragen ruwa na Irrawaddy delta key guda biyu, ya ja da baya.Prome ya mika wuya bayan wata guda.^[47] Daga nan yakin ya shiga tsawan watanni 18 inda Arakan ya bar kawancen, kuma Ava ya samu canjin shugabanci mai cike da takaddama.A cikin Disamba 1543, mafi girma sojojin da sojojin ruwa na Ava da Confederation sun sauko don sake dawo da Prome.Amma sojojin Toungoo, wadanda a yanzu sun shigar da sojojin haya na kasashen waje da bindigogi, ba wai kawai sun kori sojojin da suka fi karfin mamayewa ba, har ma sun kwace dukkan Burma ta Tsakiya har zuwa Pagan (Bagan) a watan Afrilu 1544. ^[48] A cikin lokacin rani na gaba, wani lokacin rani mai zuwa. kananan sojojin Ava sun kai hari zuwa Salin amma manyan sojojin Toungoo sun lalata su.Rashin nasarar da aka yi a jere ya kawo doguwar rashin jituwa tsakanin Ava da Mohnyin na jam'iyyar a kan gaba.Da yake fuskantar tawaye mai tsanani na Mohnyin, Ava a 1545 ya nemi kuma ya amince da yarjejeniyar zaman lafiya tare da Toungoo wanda Ava ya ba da izini ga dukan Burma ta tsakiya tsakanin Pagan da Prome.^[49] Tawayen za su mamaye Ava na tsawon shekaru shida masu zuwa yayin da Toungoo mai ƙarfin hali zai mai da hankalinsa ga cin nasarar Arakan a 1545–47, da Siam a 1547–49.