Masarautar Lan Na ta zo rikici a kan jihohin Shan da sarkin Burma mai ci, Bayinnaung.Sojojin Bayinnaung sun mamaye Lan Na daga arewa, kuma Mekuti ya mika wuya a ranar 2 ga Afrilu 1558. ^[50] Setthathirath ya ƙarfafa shi, Mekuti ya yi tawaye a lokacin Yaƙin Burma–Siamese (1563–64).Amma sojojin Burma sun kama sarkin a watan Nuwamba 1564, suka aika zuwa Pegu babban birnin Burma a lokacin.Bayinnaung sai ya sanya Wisutthithewi, Lan Na sarauta, sarauniyar Lan Na.Bayan mutuwarta, Bayinnaung ya nada ɗaya daga cikin 'ya'yansa Nawrahta Minsaw (Noratra Minsosi), mataimakiyar Lan Na a cikin Janairu 1579. ^[51] Burma ta ba da izinin samun yancin kai ga Lan Na sosai amma tana da iko sosai a kan corvée da haraji.A cikin 1720s, daular Toungoo ta kasance a kan kafafunta na ƙarshe.A cikin 1727, Chiang Mai ya yi tawaye saboda yawan haraji.Dakarun juriya sun kori sojojin Burma a 1727-1728 da 1731-1732, bayan haka Chiang Mai da Ping Valley suka sami 'yanci.^[52] Chiang Mai ya sake zama mai mulki a cikin 1757 zuwa sabuwar daular Burma.Ta sake yin tawaye a 1761 tare da ƙarfafawar Siamese amma an danne tawayen a watan Janairu 1763. A cikin 1765, Burmese sun yi amfani da Lan Na a matsayin kushin ƙaddamarwa don mamaye jihohin Laotian, da Siam kanta.