Mohammad Khodabanda was the fourth Safavid shah of Iran from 1578 until his overthrow in 1587 by his son Abbas I. Khodabanda had succeeded his brother, Ismail II. Khodabanda was the son of Shah Tahmasp I by a Turcoman mother, Sultanum Begum Mawsillu, and grandson of Ismail I, founder of the Safavid Dynasty.

After the death of his father in 1576, Khodabanda was passed over in favour of his younger brother Ismail II. Khodabanda had an eye affliction that rendered him nearly blind, and so in accordance with Persian Royal culture could not contend for the throne. However, following Ismail II's short and bloody reign Khodabanda emerged as the only heir, and so with the backing of the Qizilbash tribes became Shah in 1578.

Khodabanda's reign was marked by a continued weakness of the crown and tribal infighting as part of the second civil war of the Safavid era. Khodabanda has been described as "a man of refined tastes but weak character". As a result, Khodabanda's reign was characterised by factionalism, with major tribes aligning themselves with Khodabanda's sons and future heirs. This internal chaos allowed foreign powers, especially the rivalling and neighboring Ottoman Empire, to make territorial gains, including the conquest of the old capital of Tabriz in 1585. Khodabanda was finally overthrown in a coup in favour of his son Shah Abbas I.