A watan Agustan 1551, Turkawa Ottoman karkashin kwamandan sojojin ruwa Turgut Reis, da 'yan fashin teku Barbary sun kewaye tare da cin nasara a kan Knights na Malta a cikin Red Castle na Tripoli, wanda ya kasance mallakin Knights na Malta tun 1530. Simintin ya ƙare a cikin shida. -rana bamabamai da mika wuya a birnin ranar 15 ga watan Agusta.A shekara ta 1553 Suleiman Suleiman ya nada Turgut Reis kwamandan birnin Tripoli, wanda hakan ya sanya birnin ya zama wata muhimmiyar cibiyar hare-haren 'yan fashin teku a tekun Bahar Rum da kuma babban birnin lardin Ottoman na Tripolitania.A shekara ta 1560, an aike da wata runduna mai karfi ta ruwa domin kwato birnin Tripoli, amma an ci karfin sojojin a yakin Djerba.Dakarun na Tripoli sun yi nasarar kaiwa Malta hari a baya a watan Yuli, wanda aka dakile, da kuma nasarar mamaye garin Gozo, inda aka kwashe kiristoci 5,000 da aka yi garkuwa da su, aka kuma kai su a kan manyan motoci zuwa wurin Tripoli.