A watan Maris din shekarar 2020, a cikin rikicin siyasa, an nada Muhyiddin Yassin a matsayin Firayim Minista na takwas a Malaysia bayan murabus din Mahathir Mohamad ba zato ba tsammani.Ya jagoranci sabuwar gwamnatin hadaka ta Perikatan Nasional.Jim kadan bayan hawansa ofis, cutar ta COVID-19 ta afkawa Malaysia, wanda hakan ya sanya Muhyiddin aiwatar da dokar hana zirga-zirgar Malaysian (MCO) a cikin Maris 2020 don dakile yaduwar ta.A wannan lokaci kuma an yanke wa tsohon Firayim Minista Najib Razak hukunci bisa zargin cin hanci da rashawa a watan Yulin 2020, wanda ke zama karo na farko da firaministan Malaysia ya fuskanci irin wannan hukunci.Shekarar 2021 ta kawo ƙarin ƙalubale ga gwamnatin Muhyiddin.A cikin watan Janairu, Yang di-Pertuan Agong ya ayyana dokar ta-baci ta kasa, tare da dakatar da zaman majalisar dokoki da zabuka, tare da baiwa gwamnati damar kafa dokoki ba tare da amincewar majalisa ba, sakamakon barkewar annoba da tabarbarewar siyasa.Duk da waɗannan ƙalubalen, gwamnati ta ƙaddamar da shirin rigakafin COVID-19 na ƙasa a cikin Fabrairu.Sai dai a cikin watan Maris din da ya gabata, an yanke huldar diflomasiyya tsakanin Malesiya da Koriya ta Arewa bayan da babbar kotun Kuala Lumpur ta ki amincewa da daukaka karar da wani dan kasuwan Koriya ta Arewa ya yi ga Amurka.A watan Agustan 2021, rikicin siyasa da na kiwon lafiya ya karu, inda Muhyiddin ke fuskantar suka kan yadda gwamnati ke tafiyar da annobar da tabarbarewar tattalin arziki.Hakan ya sa ya rasa rinjayen goyon bayan majalisar.Sakamakon haka, Muhyiddin ya yi murabus daga matsayin firaminista a ranar 16 ga Agusta, 2021. Bayan murabus dinsa, Yang di-Pertuan Agong ya nada shi a matsayin firaministan rikon kwarya har sai an zabi wanda ya dace.