Yaƙin Mstislavl ya faru a ranar 4 ga Nuwamba, 1501 tsakanin sojojin Grand Duchy na Lithuania da sojojin Grand Duchy na Moscow da Principality na Novgorod-Seversk.An fatattaki sojojin Lithuania.Yaƙe-yaƙe na Muscovite-Lithuania sun sake sabuntawa a shekara ta 1500. A 1501, Ivan III na Rasha ya aika da sabuwar rundunar karkashin jagorancin Semyon Mozhayskiy zuwa Mstislavl.Sarakunan yankin Mstislavsky tare da Ostap Dashkevych ne suka shirya tsaron kuma an yi musu mugun duka a ranar 4 ga Nuwamba.Sun koma Mstislavl kuma Mozhayskiy ya yanke shawarar ba za su kai hari gidan ba.Maimakon haka, sojojin Rasha sun yi wa birnin kawanya tare da ƙwace yankunan da ke kewaye da shi.'Yan ƙasar Lithuania sun shirya rundunar agaji, wanda Great Hetman Stanislovas Kęsgaila ya kawo.Mozhayskiy da Kęsgaila dai ba su yi kus-kuri ba, kuma sojojin Rasha sun ja da baya ba tare da wani yaki ba.