Kisan kiyashin Indiya na 1622, wanda aka fi sani da kisan kiyashin Jamestown, ya faru ne a yankin Turancin Ingilishi na Virginia, wanda ke a yanzu Amurka, a ranar 22 ga Maris 1622. John Smith, ko da yake bai kasance a Virginia ba tun 1609 kuma bai kasance ba. wani shaidar gani da ido, wanda ya bayyana a cikin Tarihinsa na Virginia cewa mayaƙan Powhatan "sun zo cikin gidajenmu ba tare da makamai ba tare da barewa, turkeys, kifi, 'ya'yan itatuwa, da sauran kayan abinci don sayar da mu".Daga nan ne Powhatan suka kama duk wani kayan aiki ko makaman da suke da su kuma suka kashe duk turawan Ingila da suka samu, ciki har da maza, mata, yara na kowane zamani.Cif Opechancanough ya jagoranci kungiyar ta Powhatan a cikin jerin hare-haren ba-zata da suka hada kai, kuma sun kashe jimillar mutane 347, kashi daya bisa hudu na al'ummar yankin Virginia.Jamestown, wanda aka kafa a cikin 1607, shine wurin da aka fara samun nasarar zama na Ingilishi a Arewacin Amurka, kuma shine babban birnin Masarautar Virginia.Tattalin arzikinta na taba, wanda ya lalata ƙasa da sauri kuma ya buƙaci sabon ƙasa, ya haifar da faɗaɗa da kuma kwace filayen Powhatan akai-akai, wanda a ƙarshe ya haifar da kisan kiyashi.