The Dzungar genocide was the mass extermination of the Mongol Dzungar people by the Qing dynasty. The Qianlong Emperor ordered the genocide due to the rebellion in 1755 by Dzungar leader Amursana against Qing rule, after the dynasty first conquered the Dzungar Khanate with Amursana's support. The genocide was perpetrated by Manchu generals of the Qing army sent to crush the Dzungars, supported by Uyghur allies and vassals due to the Uyghur revolt against Dzungar rule.

The Dzungar Khanate was a confederation of several Tibetan Buddhist Oirat Mongol tribes that emerged in the early 17th century, and the last great nomadic empire in Asia. Some scholars estimate that about 80% of the Dzungar population, or around 500,000 to 800,000 people, were killed by a combination of warfare and disease during or after the Qing conquest in 1755–1757. After wiping out the native population of Dzungaria, the Qing government then resettled Han, Hui, Uyghur, and Xibe people on state farms in Dzungaria along with Manchu Bannermen to repopulate the area.