The Gulf War began with an extensive aerial bombing campaign on 16 January 1991. For 42 consecutive days and nights, the coalition forces subjected Iraq to one of the most intensive air bombardments in military history. The coalition flew over 100,000 sorties, dropping 88,500 tonnes of bombs, which widely destroyed military and civilian infrastructure. The air campaign was commanded by USAF Lieutenant General Chuck Horner, who briefly served as US Central Command's Commander-in-Chief – Forward while General Schwarzkopf was still in the US.

A day after the deadline set in Resolution 678, the coalition launched a massive air campaign, which began the general offensive codenamed Operation Desert Storm. The priority was the destruction of Iraq's Air Force and anti-aircraft facilities. The sorties were launched mostly from Saudi Arabia and the six carrier battle groups (CVBG) in the Persian Gulf and Red Sea.

The next targets were command and communication facilities. Saddam Hussein had closely micromanaged Iraqi forces in the Iran–Iraq War, and initiative at lower levels was discouraged. Coalition planners hoped that Iraqi resistance would quickly collapse if deprived of command and control.

The air campaign's third and largest phase targeted military targets throughout Iraq and Kuwait: Scud missile launchers, weapons research facilities, and naval forces. About a third of the coalition's air power was devoted to attacking Scuds, some of which were on trucks and therefore difficult to locate. US and British special operations forces had been covertly inserted into western Iraq to aid in the search for and destruction of Scuds.

Iraqi anti-aircraft defenses, including man-portable air-defense systems, were surprisingly ineffective against enemy aircraft, and the coalition suffered only 75 aircraft losses in over 100,000 sorties, 44 due to Iraqi action. Two of these losses are the result of aircraft colliding with the ground while evading Iraqi ground-fired weapons. One of these losses is a confirmed air-air victory.