On 6 September 1522, Elcano and the remaining crew of Magellan's voyage arrived in Sanlúcar de Barrameda in Spain aboard Victoria, almost exactly three years after they departed. They then sailed upriver to Seville, and from there overland to Valladolid, where they appeared before the Emperor.

When Victoria, the one surviving ship and the smallest carrack in the fleet, returned to the harbour of departure after completing the first circumnavigation of the Earth, only 18 men out of the original 270 men were on board. In addition to the returning Europeans, the Victoria had aboard three Moluccans who came aboard at Tidore.