In July 1492, the new state of Spain expelled its Jewish and Muslim populations as part of the Spanish Inquisition. Bayezid II sent out the Ottoman Navy under the command of admiral Kemal Reis to Spain in 1492 in order to evacuate them safely to Ottoman lands. He sent out proclamations throughout the empire that the refugees were to be welcomed.^[6] He granted the refugees the permission to settle in the Ottoman Empire and become Ottoman citizens. He ridiculed the conduct of Ferdinand II of Aragon and Isabella I of Castile in expelling a class of people so useful to their subjects. "You venture to call Ferdinand a wise ruler," he said to his courtiers, "he who has impoverished his own country and enriched mine!"^[7]

The Muslims and Jews of al-Andalus contributed much to the rising power of the Ottoman Empire by introducing new ideas, methods and craftsmanship. The first printing press in Constantinople (now Istanbul) was established by the Sephardic Jews in 1493. It is reported that under Bayezid's reign, Jews enjoyed a period of cultural flourishing, with the presence of such scholars as the Talmudist and scientist Mordecai Comtino; astronomer and poet Solomon ben Elijah Sharbiṭ ha-Zahab; Shabbethai ben Malkiel Cohen, and the liturgical poet Menahem Tamar.