While right-bank Ukraine belonged to the Polish–Lithuanian Commonwealth until late 1793, left-bank Ukraine had been incorporated into Tsardom of Russia in 1667 (under the Treaty of Andrusovo). In 1672, Podolia was occupied by the Turkish Ottoman Empire, while Kyiv and Braclav came under the control of Hetman Petro Doroshenko until 1681, when they were also captured by the Turks, but in 1699 the Treaty of Karlowitz returned those lands to the Commonwealth.

Most of Ukraine fell to the Russian Empire under the reign of Catherine the Great; in 1793 right-bank Ukraine was annexed by Russia in the Second Partition of Poland.

Russia, fearing separatism, imposed strict limits on attempts to elevate the Ukrainian language and culture, even banning its use and study. The Russophile policies of Russification and Panslavism led to an exodus of a number of Ukrainian intellectuals into Western Ukraine. However, many Ukrainians accepted their fate in the Russian Empire and some were able to achieve great success there. Little Russia is a geographical and historical term used to describe the modern-day territories of Ukraine.