By 248 BCE the Carthaginians held only two cities on Sicily: Lilybaeum and Drepana; these were well-fortified and situated on the west coast, where they could be supplied and reinforced without the Romans being able to use their superior army to interfere.

After more than 20 years of war, both states were financially and demographically exhausted. Evidence of Carthage's financial situation includes their request for a 2,000 talent loan from Ptolemaic Egypt, which was refused. Rome was also close to bankruptcy and the number of adult male citizens, who provided the manpower for the navy and the legions, had declined by 17 percent since the start of the war. Goldsworthy describes Roman manpower losses as "appalling".