The Battle of Settepozzi was fought in the first half of 1263 off the island of Settepozzi (the medieval Italian name for Spetses) between a Genoese–Byzantine fleet and a smaller Venetian fleet. Genoa and the Byzantines had been allied against Venice since the Treaty of Nymphaeum in 1261, while Genoa, in particular, had been engaged in the War of Saint Sabas against Venice from 1256. In 1263, a Genoese fleet of 48 ships, which was sailing to the Byzantine stronghold of Monemvasia, encountered a Venetian fleet of 32 ships. The Genoese decided to attack, but only two of the four admirals of the Genoese fleet, and 14 of its ships took part and were easily routed by the Venetians, who captured four vessels and inflicted considerable casualties.

The Venetian victory and the demonstration of Genoese reluctance to confront them had important political repercussions, as the Byzantines began to distance themselves from their alliance with Genoa and restored their relations with Venice, concluding a five-year non-aggression pact in 1268. After Settepozzi, the Genoese avoided confrontation with the Venetian navy, instead focusing on commerce raiding. This did not prevent another, even more, lopsided and complete defeat at the Battle of Trapani in 1266.