By the 980s, the Fatimids had subdued most of Syria. For the Fatimids, Aleppo was a gateway for military operations against both the Abbasids to the east and the Byzantines to the north.

The siege of Aleppo was a siege of the Hamdanid capital Aleppo by the army of the Fatimid Caliphate under Manjutakin from the spring of 994 to April 995. Manjutakin laid siege to the city over the winter, while the population of Aleppo starved and suffered from disease. In the spring of 995, the emir of Aleppo appealed for help from Byzantine emperor Basil II. The arrival of a Byzantine relief army under the emperor in April 995 compelled the Fatimid forces to give up the siege and retreat south.