In 1543, Hosokawa Ujitsuna who was the foster son of Takakuni, raised his armies, and in 1549, Miyoshi Nagayoshi who was a dominant retainer and the first son of Motonaga betrayed Harumoto and took side with Ujitsuna. Because of that, Harumoto was defeated. After Hosokawa Harumoto's fall, Miyoshi Nagayoshi and the Miyoshi clan would experience a great rise of power, and engage in a protracted military campaign against the Rokkaku and the Hosokawa. Harumoto, Ashikaga Yoshiteru who was the 13th Ashikaga shōgun and Ashikaga Yoshiharu who was the father of Yoshiteru were purged to Ōmi Province.