In 557, Khosrow I allied with the Göktürks and defeated the Hephthalites. An agreement was established between Khosrow I and the Turkic Khagan Istämi which set the Oxus as the frontier between the two empires. However, in 588, the Turkic Khagan Bagha Qaghan (known as Sabeh/Saba in Persian sources), together with his Hephthalite subjects, invaded the Sasanian territories south of the Oxus, where they attacked and routed the Sasanian soldiers stationed in Balkh, and then proceeded to conquer the city along with Talaqan, Badghis, and Herat. They were finally repelled by the Sasanian general Vahram Chobin.

The First Perso-Turkic War was fought during 588–589 between the Sasanian Empire and Hephthalite principalities and its lord the Göktürks. The conflict started with the invasion of the Sasanian Empire by the Turks and ended with a decisive Sasanian victory and the reconquest of lost lands.