The Lan Na Kingdom came to conflict over Shan states with the expansionist Burmese king Bayinnaung. Bayinnaung's forces invaded Lan Na from the north, and Mekuti surrendered on 2 April 1558.^[50] Encouraged by Setthathirath, Mekuti revolted during the Burmese–Siamese War (1563–64). But the king was captured by Burmese forces in November 1564, and sent to the-then Burmese capital of Pegu. Bayinnaung then made Wisutthithewi, a Lan Na royal, the queen regnant of Lan Na. After her death, Bayinnaung appointed one of his sons Nawrahta Minsaw (Noratra Minsosi), viceroy of Lan Na in January 1579.^[51] Burma allowed a substantial degree of autonomy for Lan Na but strictly controlled the corvée and taxation.

By the 1720s, the Toungoo Dynasty was on its last legs. In 1727, Chiang Mai revolted because of high taxation. The resistance forces drove back the Burmese army in 1727–1728 and 1731–1732, after which Chiang Mai and Ping valley became independent.^[52] Chiang Mai became a tributary again in 1757 to the new Burmese dynasty. It revolted again in 1761 with Siamese encouragement but the rebellion was suppressed by January 1763. In the 1765, the Burmese used Lan Na as a launching pad to invade the Laotian states, and Siam itself.