Following a period of stagnation after Ptolemy, the period between 250 and 350 CE is sometimes referred to as the "Silver Age" of Greek mathematics.^[53] During this period, Diophantus made significant advances in algebra, particularly indeterminate analysis, which is also known as "Diophantine analysis".^[54] The study of Diophantine equations and Diophantine approximations is a significant area of research to this day. His main work was the Arithmetica, a collection of 150 algebraic problems dealing with exact solutions to determinate and indeterminate equations.^[55] The Arithmetica had a significant influence on later mathematicians, such as Pierre de Fermat, who arrived at his famous Last Theorem after trying to generalize a problem he had read in the Arithmetica (that of dividing a square into two squares).^[56] Diophantus also made significant advances in notation, the Arithmetica being the first instance of algebraic symbolism and syncopation.^[55]