When Constantine died, the 74-year-old Theodora returned to the throne despite fierce opposition from court officials and military claimants. For 16 months she ruled as empress in her own right.

When Theodora was seventy-six, the patriarch Michael Keroularios advocated that Theodora advance a subject to the throne through marriage to her, in order to assure a succession. She refused to consider marriage, no matter how token. She also refused to name an heir to the throne. Theodora became gravely ill with an intestinal disorder in late August 1056. On 31 August her advisors, chaired by Leo Paraspondylos, met to decide whom to recommend to her as a successor. According to Psellus, they selected Michael Bringas, an aged civil servant and former military finance minister whose main attraction was that "he was less qualified to rule than he was to be ruled and directed by others". Theodora was unable to speak, but Paraspondylos decided that she had nodded at an appropriate moment. Hearing of this the Patriarch refused to believe it. Eventually he was persuaded and Bringas was crowned as Michael VI. Theodora died a few hours later and with her death, the Macedonian dynasty's 189-year rule ended.